Key Publications


PLoS Pathogens

Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface

Shaffer CL, Gaddy JA, Loh JT, Johnson EM, Hill S, Hennig EE, McClain MS, McDonald WH, Cover TL

Cell Reports

In vivo structures of the Helicobacter pylori cag type IV secretion system


Chang YW*, Shaffer CL*, Rettberg LA, Ghosal D, Jensen GJ



Peptidomimetic small molecules disrupt type IV secretion system activity in diverse bacterial pathogens


Shaffer CL, Good JA, Kumar S, Krishnan KS, Gaddy JA, Loh JT, Chappell J, Almqvist F, Cover TL, Hadjifrangiskou M


Infection and Immunity

Purine biosynthesis metabolically constrains intracellular survival of uropathogenic Escherichia coli


Shaffer CL, Zhang EW, Dudley AG, Dixon BR, Guckes KR, Breland EJ, Floyd KA, Casella DP, Algood HM, Clayton DB, Hadjifrangiskou M


  • uk logo for site

(859) 218-1168

University of Kentucky
Department of Veterinary Science
Lexington, KY, USA